Kisspeptin-10

Kisspeptin-10 is a synthetic decapeptide corresponding to the C-terminal active fragment of the kisspeptin family of neuropeptides, which are encoded by the KISS1 gene and signal through the KISS1R (GPR54) receptor. Supplied in lyophilized form for reconstitution and laboratory handling, it is studied within the broader context of neuroendocrine and reproductive-axis signaling. This product is provided strictly for research and professional laboratory use and is not approved by the FDA for therapeutic use; nothing here should be read as a therapeutic, diagnostic, or treatment claim. It is organized under the platform's Cognitive and Longevity reference category because of investigational interest in the hypothalamic-pituitary-gonadal (HPG) axis and its reported relationship to endocrine, metabolic, and neurobehavioral pathways explored in the scientific literature. Individual results vary across models and experimental conditions.

• Investigated in research literature for its reported role in activating the hypothalamic-pituitary-gonadal (HPG) axis and modulating gonadotropin-releasing hormone (GnRH) signaling (individual results vary)
• Studied as a research probe for reproductive endocrinology and the regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in model systems (individual results vary)
• Examined in the scientific literature for its reported relationship to puberty onset and neuroendocrine timing in model systems (individual results vary)
• Explored in research settings for proposed links between kisspeptin signaling and neurobehavioral, mood, and limbic-pathway processes (individual results vary)
• Referenced in investigational work on the interface between metabolic state, energy balance, and reproductive-axis regulation (individual results vary)

Reference handling information only. This compound is typically supplied as a lyophilized powder and is commonly reconstituted with bacteriostatic or sterile water for laboratory use; gentle swirling rather than vigorous shaking is generally preferred to help preserve peptide integrity. Lyophilized material is generally stored frozen and kept protected from light and moisture, while reconstituted solution is generally kept refrigerated and protected from light per standard peptide-handling references. Repeated freeze-thaw cycles are generally avoided. The names GLP-1, GLP-2, and GLP-3 referenced elsewhere in this catalog are SKU identifiers only and imply no claim about this product. All clinical protocols, dosing, and any patient-related decisions are determined solely by the licensed ordering provider; this is reference information for research and professional use only and is not medical advice.

A per-lot Certificate of Analysis, HPLC purity profile, and mass-spectrometry verification are available on request for this product. Ask your account manager for the current lot documentation.

In the available literature, Kisspeptin-10 is described as acting as an agonist at the KISS1R (GPR54) receptor, a G-protein-coupled receptor reported to be expressed on GnRH neurons in the hypothalamus. Binding is described in research as initiating intracellular signaling cascades (including phospholipase C activation and downstream calcium mobilization) that have been associated with the pulsatile release of gonadotropin-releasing hormone, which in turn has been linked in investigational models to luteinizing hormone and follicle-stimulating hormone secretion from the anterior pituitary. This proposed upstream position within the HPG axis is the primary basis for its interest as a research tool. Reported effects in the literature vary across models and experimental conditions, and individual results vary.