SS-31

SS-31 (also referenced in the scientific literature as elamipretide or within the Szeto-Schiller peptide series) is a small, synthetically produced, aromatic-cationic tetrapeptide supplied as a lyophilized powder for reconstitution. It is characterized in the research literature by its reported affinity for cardiolipin, a phospholipid concentrated in the inner mitochondrial membrane, which underlies its frequent description as a "mitochondria-targeted" peptide. In a B2B catalog context, SS-31 is grouped within the Cognitive and Longevity category because much of its preclinical and exploratory investigation centers on mitochondrial bioenergetics, oxidative-stress biology, and age-associated cellular processes. This entry is provided as professional reference information for licensed practitioners ordering wholesale research material. SS-31 is not approved by the FDA for therapeutic use and is supplied strictly for research and professional use; any application is at the sole discretion of the ordering provider, and individual results vary.

• Investigated in preclinical and exploratory literature for its reported interaction with mitochondrial bioenergetics and cellular ATP-related pathways; individual results vary
• Studied in research models in the context of oxidative stress and reactive-oxygen-species biology; individual results vary
• Examined in the scientific literature in relation to age-associated mitochondrial decline and cellular-aging processes; individual results vary
• Explored in research settings for cardiac and skeletal-muscle mitochondrial function as model systems; individual results vary
• Referenced in cognitive and neurological research literature in connection with neuronal mitochondrial energetics; individual results vary

Reference handling information: SS-31 is typically supplied as a lyophilized powder and reconstituted with bacteriostatic or sterile water added slowly against the vial wall, then swirled gently rather than shaken until fully dissolved. Unreconstituted lyophilized vials are generally stored refrigerated and, for longer-term holding, may be kept frozen; once reconstituted, the solution is commonly kept refrigerated, protected from light, and handled using standard aseptic technique. As with many peptides, exposure to heat, repeated freeze-thaw cycles, and direct light should be minimized to help preserve stability. This is reference information only and not medical advice; all clinical protocols, including any decision to use, dosing, and administration, are determined solely by the licensed ordering provider.

A per-lot Certificate of Analysis, HPLC purity profile, and mass-spectrometry verification are available on request for this product. Ask your account manager for the current lot documentation.

The proposed mechanism described in the research literature centers on the reported binding of SS-31 to cardiolipin within the inner mitochondrial membrane. By associating with cardiolipin, the peptide is described in preclinical studies as potentially influencing the architecture of the electron transport chain and the efficiency of cellular respiration, with reported downstream effects on ATP-related output and the generation of reactive oxygen species. Because this binding concentrates the peptide at the mitochondrial membrane rather than at a single enzymatic target, investigators often characterize its studied activity as broadly affecting mitochondrial integrity and bioenergetic balance. These mechanisms are described as proposed or under investigation, are drawn from research models, and have not been established for any therapeutic use; individual results vary.