Melanotan 1

Melanotan 1 (also referenced in the literature as Melanotan-I or afamelanotide) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (alpha-MSH), a member of the melanocortin peptide family. It is supplied as a lyophilized powder for reconstitution and is intended strictly for laboratory research and professional reference use by licensed practitioners. This compound is not approved by the FDA for therapeutic use and is not offered for personal use, self-administration, or as a finished drug product. As a melanocortin-system analog, it has drawn interest across pharmacology, dermatology, and broader longevity-adjacent research programs that study melanocortin receptor signaling and pigment biology. All descriptions here are provided as professional reference information for qualified investigators and ordering clinicians; individual results vary.

• Investigated in preclinical and dermatological research literature for its interaction with melanocyte-stimulating hormone pathways and pigment-related biology; individual results vary.
• Studied as a tool compound for exploring melanocortin-1 receptor (MC1R) signaling and downstream cellular responses; individual results vary.
• Referenced in photobiology research examining cutaneous responses to ultraviolet exposure in model systems; individual results vary.
• Examined in academic literature as a structural analog for understanding alpha-MSH peptide stability and receptor-binding characteristics; individual results vary.
• Explored within melanocortin-system research relevant to longevity-adjacent and oxidative-stress investigative programs; individual results vary.

Reference handling information only: the lyophilized peptide is typically reconstituted with bacteriostatic water and gently swirled rather than shaken until fully dissolved. The sealed, unopened vial is generally stored frozen or refrigerated and protected from light and moisture; once reconstituted, the solution is commonly kept refrigerated, shielded from light, and used within a limited window per laboratory standard practice. Lyophilized material should be returned to cold storage promptly and protected from repeated temperature cycling and direct light. This compound is not approved by the FDA for therapeutic use and is provided for research and professional use only. All reconstitution parameters, concentrations, and any clinical protocols are determined solely at the discretion of the licensed ordering provider; this is reference information for professional use, not medical advice.

A per-lot Certificate of Analysis, HPLC purity profile, and mass-spectrometry verification are available on request for this product. Ask your account manager for the current lot documentation.

In the research literature, Melanotan 1 is described as an analog of alpha-MSH that is reported to bind melanocortin receptors, with particular investigative emphasis on the melanocortin-1 receptor (MC1R) expressed by melanocytes. Studies propose that receptor engagement is associated with activation of adenylate cyclase and elevated intracellular cyclic AMP, which has been examined in model systems in connection with melanogenesis and the synthesis of eumelanin. Its modified peptide structure is reported to be associated with greater metabolic stability and a longer duration of receptor interaction relative to native alpha-MSH in studied systems. These mechanistic descriptions reflect proposed and studied pathways from preclinical and in vitro research only and do not constitute therapeutic claims; individual results vary.