Melanotan 2

Melanotan 2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH), supplied here in lyophilized form for laboratory research and professional reference use only. As a non-selective agonist at melanocortin receptors, it has been employed as a tool compound in preclinical and exploratory investigations of the melanocortin signaling system. Melanotan 2 is not approved by the FDA for therapeutic use and is provided strictly for research and professional purposes; it is not intended to diagnose, treat, cure, or prevent any condition. This entry is professional reference information for licensed ordering practitioners and is not patient-directed marketing.

• Investigated in preclinical literature as a tool compound for studying melanocortin receptor pharmacology and downstream signaling
• Studied in research models in connection with melanocortin-mediated pigmentation signaling pathways (melanogenesis); individual results vary
• Examined in exploratory research contexts relating to central melanocortin pathways implicated in appetite and energy-balance signaling; individual results vary
• Used as a comparator or reference ligand in structure-activity and receptor-binding research on melanocortin analogs
• Referenced in laboratory research characterizing the stability and receptor-activity profile of melanocortin peptide analogs relative to native alpha-MSH

Supplied as a lyophilized powder for laboratory handling. General reference practice for peptides of this class is to reconstitute with bacteriostatic water or another suitable sterile diluent appropriate to the research protocol, adding the diluent slowly against the vial wall and allowing the powder to dissolve without vigorous agitation. Lyophilized vials are commonly stored frozen or refrigerated and kept sealed until use; once reconstituted, the solution is generally kept refrigerated and protected from light and excessive heat. Repeated freeze-thaw cycles and prolonged exposure to direct light should be avoided. All clinical and research protocols, including any reconstitution concentrations, handling decisions, storage durations, and use parameters, are determined solely by the licensed ordering provider; this is reference information only and does not constitute medical advice.

A per-lot Certificate of Analysis, HPLC purity profile, and mass-spectrometry verification are available on request for this product. Ask your account manager for the current lot documentation.

Melanotan 2 is described in the research literature as a non-selective agonist of the melanocortin receptor family (including MC1R and MC4R, among others). Engagement of MC1R on melanocytes is reported in preclinical work to be associated with intracellular cyclic AMP signaling and related melanogenesis pathways, while activity at central MC4R has been a focus of investigations into appetite and energy-balance signaling. Its relative resistance to enzymatic degradation compared with native alpha-MSH has made it a frequently studied tool molecule for probing melanocortin pathway activity in experimental systems. Proposed mechanisms remain the subject of ongoing research, and individual results vary.